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Vasa vasorum of the coronary arteries in an animal heart model
Patzelt, Matěj ; Stingl, Josef (advisor) ; Laichman, Stanislav (referee) ; Slížová, Dáša (referee)
The vasa vasorum of the coronary arteries is a system of tiny vessels that nourish the wall of the coronary arteries. Recently, the vasa vasorum has been attributed importance in the pathogenesis of atherosclerosis, necrosis of the tunica media, or in excessive healing of the intima after stenting. The vasa vasorum system is described in detail on pathologically altered hearts, however, studies that would deal with a detailed description on a healthy human heart or on its animal model are minimal. The aim of the dissertation was to describe the structure and origin of the vasa vasorum of the coronary arteries on an animal model of the heart of a pig, to describe the history of the term vasa vasorum and possibly to describe secondary findings on the examined samples. A total of 36 healthy pig hearts were used in the study. Part of them was injected with India ink through the ostium of the coronary arteries and subsequently histologically processed, other hearts were directly fixed in toto in formalin and histologically processed, the remaining part of the hearts was injected through the ostium of the coronary arteries with mercox resin and then corrosive casts of the coronary arteries were created. These samples were evaluated using a scanning electron microscope. Histological processing of the...
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Morphology of the Abdominal Aortic Aneurysm
Eberlová, Lada ; Valenta, Jiří (advisor) ; Stingl, Josef (referee) ; Šebesta, Pavel (referee)
Dissertation Abstract Abdominalaortic aneurysm (AAA) is a serious disease. Its prevalence is in the developed countries about 3%. As an aneurysm is considered a dilatation of all layers of a vessel wall over 3 cm. Majority of AAA are small and asymptomatic, and although the risk of rupture increases with the size of aneurysm sack, even the small aneurysms rupture. The rupture mortaliry ranges about 70 %. Surgical treatment is indicated in the asymptomatic patients in diameter of AAA over 5 cm. The average speed of growth of AAA is 0.3 cm per year, e.g. in the early diagnosed patients there is a several years interval for a pharmacolocical influencing of the progression of this disease. Knowledge of pathogenesis is essential for any targeted pharmacological treatment. Our prospective, non-randomised studies are based on the application of the stereological methods for the histopathological assessment of the AAA samples. The acquired data enable the statistical analysis, including the null hypothesis testing. In our study analyzing the histopathology of AAA aortae of 65 patients (65 walls and 55 thrombi) and 6 normal abdominal aortae from the organ donors we assessed the following parameters: the area fractions of collagen and elastin, and the length density of elastin in intima and media, the area...
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Morphology of the Abdominal Aortic Aneurysm
Eberlová, Lada ; Valenta, Jiří (advisor) ; Stingl, Josef (referee) ; Šebesta, Pavel (referee)
Dissertation Abstract Abdominalaortic aneurysm (AAA) is a serious disease. Its prevalence is in the developed countries about 3%. As an aneurysm is considered a dilatation of all layers of a vessel wall over 3 cm. Majority of AAA are small and asymptomatic, and although the risk of rupture increases with the size of aneurysm sack, even the small aneurysms rupture. The rupture mortaliry ranges about 70 %. Surgical treatment is indicated in the asymptomatic patients in diameter of AAA over 5 cm. The average speed of growth of AAA is 0.3 cm per year, e.g. in the early diagnosed patients there is a several years interval for a pharmacolocical influencing of the progression of this disease. Knowledge of pathogenesis is essential for any targeted pharmacological treatment. Our prospective, non-randomised studies are based on the application of the stereological methods for the histopathological assessment of the AAA samples. The acquired data enable the statistical analysis, including the null hypothesis testing. In our study analyzing the histopathology of AAA aortae of 65 patients (65 walls and 55 thrombi) and 6 normal abdominal aortae from the organ donors we assessed the following parameters: the area fractions of collagen and elastin, and the length density of elastin in intima and media, the area...
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